Research Impact:
Assistant Professor Dr Ravishankar Ram Mani
Assistant Professor
Academic Qualifications
PhD in Biomedical Genetics
MSc. in Biochemistry
BSc. in Biochemistry
Areas of Interest
North American Association of Obesity Research (NAASO)
American Society for Microbiology (ASM)
Research Title: “Impact of SARS-CoV-2 Infection on Proteomic Profile and Host Immune Responses.” Principal Investigator: Ravishankar Ram Mani, Dept. of Pharmaceutical Biology, 五一吃瓜官网 University, Kuala Lumpur, Malaysia.
Start Date: 29-05-22; Funding Agency: CERVIE – 五一吃瓜官网
· Research Title: “Invitro and in vivo evaluation of the ameliorative effect of standardized TC-16 polyherbal formulation in murine uterine fibroid and dysmenorrhea model” Co-Investigator: Ravishankar Ram Mani, Dept. of Pharmaceutical Biology, 五一吃瓜官网 University, Kuala Lumpur, Malaysia.
Start Date: 06-22; Funding Agency: CERVIE – 五一吃瓜官网
· Research Title: “Evaluation and comparison of short chain fatty acids composition in gut diseases” Co-Investigator: Ravishankar Ram Mani, Dept. of Pharmaceutical Biology, 五一吃瓜官网 University, Kuala Lumpur, Malaysia.
Start Date: 10-02-21; Funding Agency: TRGS – MOHE
Industrial Consultancy Grant:
· Title: “Standardization and Formulation of Capsule Loaded with TC7 Chitosan Nanoparticles & Its Evaluation on Human Cervical Cancer Cell Line in vitro and in vivo” Co-Investigator: Ravishankar Ram Mani, Dept. of Pharmaceutical Biology, 五一吃瓜官网 University, Kuala Lumpur, Malaysia.
Start Date: 10-02-23; Funding Agency: Industrial Consultancy Grant
Supervision:
PhD students (Current)
Mr. Lan Boo
PhD students (Completed)
Master students (Current)
Sarah Maisha Binti Rasid
Master students (Completed)
Undergraduate students (Current)
Undergraduate students (Completed)
1. Ravishankar Ram M, Beena G, Preethi Raghunathan and Malathi R.
Analysis of Structure, Function and evolutionary origin of the Ob Gene Product – Leptin. J. Biomol. Str. Dyn. 2007 Oct; 25(2):183-8. PMID: 17718597. (Q1; Impact Factor: 5.235)
2. Ravishankar Ram M, Sundararaman P.G, Selvi M and Malathi R.
Possible correlation of leptin with body fat distribution and adiposity: Evaluation of serum leptin in South Indian population. (Springer) Reprod Med Biol. 2007: 6 (2): 117-125(9). PMID: 29699270. (Q1; Impact Factor: 4.009)
3. Ravishankar Ram M, Sundararaman P.G, Selvi M, and Malathi R.
Cytokines and leptin correlation in patients with PCOS: Biochemical evaluation in South Indian population. (Springer) Reprod Med Biol. 2005 Nov 2;4(4):247-254. PMID: 29699227. (Q1; Impact Factor: 4.009)
4. Ravishankar Ram M, Sundararaman P.G, and Malathi R.
Body fat distribution and leptin correlation in women with polycystic ovary syndrome: Endocrine and biochemical evalution in South Indian Population. (Springer) Reprod Med Biol. 2005: 4; 71 – 78. PMID: 29699212. (Q1; 4.009)
5. Ravishankar Ram M, Khean Lee Goh, Alex H.R. Leow, Bee H. Poh, Mun F. Loke, Richard Harrison, Esaki M. Shankar, Jamuna Vadivelu.
Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter Pylori Infection. PLOS ONE doi: 10.1371/journal.pone.0141865. PMID: 26559190. (Q1; Impact Factor: 3.94)
6. Ravishankar Ram M, Xinsheng Teh, Tamayanthi Rajakumar, Khean Lee Goh, Alex Hwong Ruey Leow, Bee Hoon Poh, Vanitha Mariappan, Esaki M. Shankar, Mun Fai Loke1, and Jamuna Vadivelu*
Polymorphisms in the host CYP2C19 gene and antibiotic-resistance attributes of Helicobacter pylori isolates influence the outcome of triple therapy. Antimicrob Chemother. PMID: 30403784. (Q1; Impact Factor: 5.217)
7. Ravishankar Ram M, P. Shanthi, Malathi Raghunathan.
Expression of leptin (ob gene product) in reproduction system with special reference to polycystic ovary syndrome. International Journal of Health Research, 2010; 3(3): 165-177. (Q2; Impact Factor: 1.0)
8. Barathan Muttiah, Rosmawati Mohamed, Jamuna Vadivelu, Li Yen Chang, Ramachandran Vignesh, Ravishankar Ram M, Vijayakumar V, Marie Larsson, Shankar EM.
CD8+ T cells of chronic HCV-infected patients express multiple negative immune checkpoints following stimulation with HCV peptides. Cellular Immunology – PMID: 28104239, Elsevier Publication – 2017. (Q1; Impact Factor: 4.868)
9. Barathan Muttiah, Rosmawati Mohamed, Rada Elleg?rd, Alireza Saeidi, Jamuna Vadivelu, Abdul W. Ansari, Hussin A. Rothan, Ravishankar Ram M, Vijayakumar Velu, Marie Larsson, Tunku Kamarul, Shankar Esaki Muthu.
Peripheral Loss of CD8+CD161brightTCR Vα7.2+ MAIT Cells in chronic HCV-infected patients. Eur J Clin Invest. 2016 Feb; 46(2):170-80. PMID: 26681320. (Q1; Impact Factor: 5.217)
10. Barathan Muttiah, Rosmawati Mohamed, Alireza Saeidi, Jamuna Vadivelu, Li Y. Chang, Kaliappan Gopal, Ravishankar Ram M, Abdul W. Ansari, Adeeba Kamarulzaman, Vijayakumar Velu, Marie Larsson, and Esaki M. Shankar.
Increased frequency of late-senescent T cells lacking CD127 in chronic hepatitis C disease. Eur J Clin Invest 2015; 45 (5): 466–474. PMID: 25721991. (Q1; Impact Factor: 5.217)
11. Barathan Muttiah, Kaliappan Gopal, Rosmawati Mohamed, Rada Elleg?rd, Alireza Saeidi, Jamuna Vadivelu, Abdul W. Ansari, Hussin A. Rothan, Ravishankar Ram M, Vijayakumar Velu, Marie Larsson, Tunku Kamarul, Shankar Esaki Muthu.
Chronic hepatitis C virus infection triggers spontaneous differential expression of bio signatures associated with T-cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. Apoptosis. 2015 Apr; 20 (4):466-80. PMID: 25577277. (Q1; Impact Factor: 4.87)
12. Gopal K, Gowtham M, Sachin S, Ravishankar Ram M, Esaki M Shankar3 and Kamarul T.
Attrition of Hepatic Damage Inflicted by Angiotensin II with α-Tocopherol and β-Carotene in Experimental Apolipoprotein E Knock-out Mice. Sci. Rep. 5, 18300. PMID: 26670291. (Q1; Impact Factor: 5.23)
13. Asweni B, Chua KH, Vikineswary S, Ravishankar Ram M, Kuppusamy UR.
Pleurotus Giganteus (Berk. Karun & Hyde), the Giant Oyster Mushroom Inhibits NO Production in LPS/H2O2 Stimulated RAW 264.7 Cells via STAT 3 and COX-2 Pathways. BMC Complementary and Alternative Medicine – (2017) 17:40. PMID: 28086773. (Q1; Impact Factor: 3.5)
14. Tan X.C, Chua K.H, Ravishankar Ram M, Kuppusamy U.R.
Monoterpenes: Novel insights into their biological effects and roles on glucose uptake and lipid metabolism in 3T3-L1 adipocytes. Food Chem. 2016 Apr 1; 196:242-50. PMID: 26593489. (Q1; Impact Factor: 7.514)
15. Puvaneswari P, Chua KH, Nurestri AM, Vikineswary S, Ravishankar Ram M, Kuppusamy UR.
Giant Oyster Mushroom Pleurotus giganteus (Agaricomycetes) Enhances Adipocyte Differentiation and Glucose Uptake via Activation of PPARγ and Glucose Transporters 1 and 4 in 3T3-L1 Cells. International Journal of Medicinal Mushrooms, 18(9): 821–831 (2016). PMID: 27910773. (Q1; Impact Factor: 2.1)
16. Rahim MRA, Tan JAMA, Ravishankar Ram M, Kuppusamy UR.
Non-invasive Sampling for Assessment of Oxidative Stress and Pro-Inflammatory
Cytokine Levels in Beta-Thalassaemia Major Patients. Rev Romana Med Lab. 2016; 24(1):83-92. (Q2; Impact Factor: 1.26)
17. Jayaraj R, Kumaraswamy C, Shetty S, Raymond G, Ram MR, Govind SK, Chandramoorthy HC, Shaw P.
Clinical approaches to interpreting the findings of systematic review and meta-analysis of the effectiveness of probiotics in the prevention and treatment of Cancer Therapy-Induced Oral Mucositis (CTIOM). Oral Oncol. 2020 Feb 27:104622. (ISI Journal, Q1, Impact factor: 4.0) PMID: 32115371. (Q1; Impact Factor: 4.109)
18. Jayaraj R, Kumaraswamy C, Shetty S, Raymond G, Ram M R, Govind SK, Chandramoorthy HC, Shaw P.
Diagnostic implications of miRNAs in Liquid Biopsy for Oral Squamous Cell Carcinoma (OSCC): Clinical validity and interpretation. Oral Oncol. 2020 Mar 11: 104634. PMID: 32171663. (Q1; Impact Factor: 4.109)
19. Jayaraj R, Shetty S, Kumaraswamy C, Raymond G, Ram MR, Govind SK, Chandramoorthy HC, Shaw P.
Clinical validity of clinicopathological and prognostic significance of circulating tumor cells in head and neck squamous cell carcinoma. Oral Oncol. 2020 Apr 20:104727. PMID: 32327312. (Q1; Impact Factor: 4.109)
20. Rama Jayaraj, Greg Raymond, Sunil Krishnan, Katherine S. Tzou, Siddhartha Baxi, Ravishankar Ram M, Suresh Kumar Govind, Harish C Chandramoorthy, Faisal Abukhzam and Peter Shaw.
Clinical Theragnostic Potential of Diverse miRNA Expressions in Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers (MDPI) 2020, 12, 1199. PMID: 32397507 (Q1; Impact factor: 6.2).
21. Rama Jayaraj, Kumaraswamy C, Shetty S, Ravishankar Ram M, Peter Shaw.
Clinical and conceptual comments on “Risk factors of critical & mortal COVID-19 cases”: A systematic literature review and meta-analysis. Journal of Infection, PMID: 32407756 (Q1, Impact factor: 5.0).
22. Rama Jayaraj, Greg Raymond, Sunil Krishnan, Siddhartha Baxi, Ravishankar Ram M, Suresh Kumar Govind, Faisal N. Abu-Khzam, Peter Shaw.
Clinical validity and Conceptual interpretation of Systematic review and meta-analysis on Elective Neck Dissection (END) versus observation for early-stage oral squamous cell carcinoma (OSCC). Oral Oncol. PMID: 32402654. (Q1; Impact Factor: 4.0)
23. Rama Jayaraj, Sameep Shetty, Chellan Kumarasamy, S Raghul, K M Gothandam, Greg Raymond, Ravishankar Ram M, Peter Shaw.
Clinical comments on prognostic and clinic pathological significance of PD-L1 overexpression in oral squamous cell carcinoma (OSCC). Oral Oncol. PMID: 32684328. (Q1, Impact factor: 4.0).
24. Rama Jayaraj, Sameep Shetty, Chellan Kumarasamy, Gothandam KM, Ravishankar Ram M, Peter Shaw.
Clinical Interpretation of findings from A systematic review and a comprehensive meta- analysis on Clinic pathological and prognostic characteristics of oral squamous cell carcinomas (OSCC) arising in patients with oral lichen planus (OLP). Oral. Oncol. PMID: 32798186. (Q1; Impact Factor: 4.0)
25. Rama Jayaraj, Chellan Kumarasamy, Ravishankar Ram M, Gothandam KM, Devi A and Peter Shaw.
Preparing for a COVID-19 pandemic: a review of outbreak response measures from Australia perspective. Trends in Res, 2020; Vol.3: 1-2 doi: 10.15761/TR.1000163.
26. Rama Jayaraj, Peter Shaw, Sameep Shetty, Chellan Kumarasamy, Gothandam KM, Ravishankar Ram M, and Siddhartha Baxi.
Comment on Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis. British Journal of Cancer (BJC 2021 Apr 12.) PMID: 33846522. (Q1; Impact Factor: 7.64)
27. A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis
SBRJ Peter Shaw, Raghul Senthilnathan, Sunil Krishnan, Deepa Suresh, Sameep.
Cancers (MDPI) 17 (13), 4369. PMID: 34503179. (Q1; Impact Factor: 6.639)
28. M. Ravishankar Ram, Rama Jayaraj. Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis. Genes - MDPI 12, 2021. PMID: 34946979. (Q1; Impact Factor: 4.096)
29. Ravishankar Ram M, Rama Jayaraj. Conceptual interpretation and clinical applicability of a systematic review and meta-analysis about prognostic value of apolipoproteins in COVID-19 patients. Travel Medicine and Infectious Disease, 2022. PMID: 34990864. (Q1; Impact Factor: 6.211)
30. Ravishankar Ram M, Rama Jayaraj. Molecular Investigation of miRNA Biomarkers as Chemoresistance Regulators in Melanoma: A Protocol for Systematic Review and Meta-Analysis. Genes – MDPI; 13, 115: 2022. PMID: 35052456. (Q1; Impact Factor: 4.096)
31. Ravishankar Ram M, Rama Jayaraj. COVID-19 Outcomes in Patients Hospitalised with Acute Myocardial Infarction (Ami): A Protocol for Systematic Review and Meta-Analysis. COVID – MDPI; 2 (2): 138-148, 2022.
32. Ravishankar Ram Mani, Rama Jayaraj. Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis. Pathophysiology-MDPI 2022, 29, 66–80. (Q1; Impact Factor: 6.012).
33. Rajagopal MS, Senthilnathan R, Km G, Ram MR, Samiappan S, Jayaraj R. Conceptual and Statistical Interpretation of a Systematic Review and Meta-Analysis on Patient Adherence to Lung-RADS–Recommended Screening Intervals in the United States. Journal of Thoracic Oncology 2022; Vol. 17 No. 3: e25-e44. (Q1; Impact Factor: 15.61).
34. Ravishankar Ram Mani, Rama Jayaraj. A Clinical Investigation on the Theragnostic Effect of microRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis. Genes – MDPI March 2022 13(3):463. (Q1; Impact Factor: 4.096)
35. Ravishankar Ram Mani, Rama Jayaraj. Bibliometric and Density Visualisation Mapping Analysis of Domestic Violence in Australia Research Output 1984-2019. Int J Environ Res Public Health. 2022 Apr 15;19(8):4837. PMID: 35457702; PMCID: PMC9029041. (Q1; Impact Factor: 3.39)
36. Ravishankar Ram Mani, Sasikala Chinappan. Application of Nanoantibiotics approach against anti- bacterial resistance. International Journal of Applied Pharmaceutics, 2022;14(3):34-39.
37. Ravishankar Ram Mani, Chandramathi Samundi (2022). Host immune response against DENV and ZIKV infections. Front. Cell. Infect. Microbiol. 12:975222 (Q1, IF 6.073). DOI: 10.3389/fcimb.2022.975222.
38. Ravishankar Ram Mani, Jayaraj R, Polpaya, et al. Clinical Investigation of Chemotherapeutic Resistance and miRNA Expressions in Head and Neck Cancers: A Thorough PRISMA Compliant Systematic Review and Comprehensive Meta-Analysis. Genes (Basel). 2022;13(12):2325 (Q1, IF 4.141). doi:10.3390/genes13122325
39. Ravishankar Ram Mani, Sasikala Chinnappan, et al. Nanotechnology in the Treatment of Infectious Diseases: A Review. International Journal of Nanoscience and Nanotechnology, 19, 1, 2023, 1-8. doi: 10.22034/ijnn.2023.531029.2056
40. Ravishankar Ram Mani, Balasubramani Ravindran, et al. Exploring the therapeutic potential of Decalepis hamiltonii root extract: synthesis of gold nanoparticles and assessment of antimicrobial, antioxidant, and anti?proliferative activities. Applied Nanoscience 2023(Q1, IF 3.869, https://doi.org/10.1007/s13204-023-02858-7
41. Ravishankar Ram Mani, Balasubramani Ravindran, et al. Seasonal influence on physicochemical properties of the sediments from Bay of Bengal coast with statistical approach. Environmental Research 2023 (Q1, IF 8.431), https://doi.org/ 10.1016/j.envres.2023.116611
42. Ravishankar Ram Mani, Chandramathi Samundi, et al. Antibacterial and antibiotic potentiating capabilities of extracts isolated from Burkillanthus malaccensis, Diospyros hasseltii and Cleisthanthus bracteosus against human pathogenic bacteria. Tropical Biomedicine 40(2): 152-158 (2023) (Q1, IF 1.023). doi.org/10.47665/tb.40.2.004.
43. Ravishankar Ram Mani, Vinod Kumar Nelson, et al. Reactive Oxygen Species Mediated Apoptotic Death of Colon Cancer Cells: Therapeutic Potential of Plant Derived Alkaloids. Front. Endocrinol.Sec. Cellular Endocrinology Volume 14 – 2023 (Q1, IF 6.45) doi: 10.3389/fendo.2023.1201198.
44. Ravishankar Ram Mani, Balasubramani Ravindran, et al. The potency of hydrothermally prepared sulfated silica (SO4/SiO2) as a heterogeneous acid catalyst for ethanol dehydration into diethyl ether, Chemosphere (2023), doi: doi.org/10.1016/j.chemosphere.2023.139822. (Q1, IF 9.0)
2005–2010, Indian Counsel of Medical Research (ICMR) Grant Peer Review Committee
2014– Present, BMC Journal (Invited for peer Review).
2017 – 2018, Cellular Physiology and Biochemistry Journal (Invited for peer Review).
2018 – PLoS ONE (Invited for peer Review).
2020 - Present, World Journal of Surgical Oncology (Invited for peer Review)
2020 – Present, Journal of Gynecology and Women Healthcare (JGWH) (Invited for peer Review)
2021- Present, Technology in Cancer Research & Treatment (Invited for peer Review)
2021- Present, Editorial Board member: Clinicals in Oncology https://clinicalsinoncology.com/editorial-board.php
2021- Present, Editorial Board member: Archives of Hematology & Oncology https://hematologyoncology.contusm.com/editorial-board.php
? Young Scientist Award - Czech Science Foundation (CSF) Training Fellowship Programme | Department of Molecular biology & Genetics | UNIVERSITY OF SOUTH BOHEMIA, FACULTY OF SCIENCE, BRANI?OVSK?, ?ESK? BUD?JOVICE, CZECH REPUBLIC
? Indian Council of Medical Research, Junior & Senior Research Fellowship Grant – A study towards molecular screening in women with PCOD from Chennai base population – Estimation of ob protein(Serum Leptin) obmRNA expression in obese subjects; Role: Junior Research Fellow & Senior Research Fellow; Year: 23.02.2004 to 22.02.2006 (Supervisor: Malathi Raghunathan); Field of Research: Biomedical Sciences; Source of Funding: ICMR, Ministry of Human Resources, Government of India, New Delhi (Award No. 45/9/03/JRF/SRF 2004– BMS, 07/01/04).
